Literature summary extracted from

Ryden, M.; Jocken, J.; van Harmelen, V.; Dicker, A.; Hoffstedt, J.; Wiren, M.; Blomqvist, L.; Mairal, A.; Langin, D.; Blaak, E.; Arner, P.
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis (2007), Am. J. Physiol. Endocrinol. Metab., 292, E1847-E1855.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.79	additional information	hormone-sensitive lipase is knocked down by RNA interference or selectively inhibited	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.79	Homo sapiens	Q05469	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.79	adipocyte	women with polycystic ovary syndrome or obesity have significantly decreased expression of hormone-sensitive lipase. Knock down of hormone-sensitive lipase by RNAi reduces basal and catecholamine-induced lipolysis. Treatment of mesenchymal stem cells with a selective inhibitor of hormone-sensitive lipase during and/or after differentiation in adipocytes reduces basal lipolysis by 50%	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)